Our paper Relating protein adduction to gene expression changes: a systems approach is featured on the cover of the July issue of the Molecular Biosystems. It is also highlighted in Vanderbilt’s Reporter and evaluated by the Faculty of 1000 (F1000). As stated in the F1000 evaluation, “These researchers used powerful systems biology strategies to uncover mechanisms linking adduction of individual proteins by 4-hydroxynonenal to global changes in gene expression that accompany cellular exposure to this noxious lipid-derived electrophile. …… This paper highlights the capability of integrative approaches to generate new hypotheses to explain the pathogenesis of diseases that involve toxic electrophiles”. A pdf file of the paper with the Molecular Biosystems cover can be downloaded here.
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